Producer or Distributor
(address or phone number, and website)

Pfizer Canada Inc.
17300 Trans-Canada Highway,
Montreal, QC
H9J 2M5
www.pfizer.ca

Janssen-Ortho Inc.
19 Greenbelt Drive,
Toronto, ON
M3C 1L9
www.janssen-ortho.com

Novartis Pharma Canada Inc.
385 Bouchard Blvd, Montreal, QC
H9R 4P5
www.novartis.ca

Lundbeck Canada Inc.
(1-866-880-4636)
www.lundbeck.com

Indication(s) in Alzheimer's Disease and related dementias

Symptom treatment - mild, moderate and severe Alzheimer's disease

Symptom treatment - mild to moderate Alzheimer's disease and mild to moderate dementia

Symptom treatment - mild to moderate Alzheimer's disease

Symptom treatment - moderate to severe Alzheimer's disease

Dosages available

Tablets:

• 5 mg (white)
• 10 mg (yellow)

[Same for Rapidly Disintegrating Tablets (RDT) formulation]

Capsules:

• 1.5 mg (yellow)
• 3 mg (orange)
• 4.5 mg (red)
• 6 mg (orange & red)

Oral solution:

• 2 mg/mL

Skin patch (new)

Capsules:

• 8 mg (white)
• 16 mg (pink)
• 24 mg (caramel)

Tablet:

• 10 mg (white - scored)

Oral solution:

• 10 mg/mL

Cost per day
(unless covered by drug plan)

~ $5.00

~ $5.00

~ $5.00

~ $5.00

Most common side effects
(seen in > 5% of patients in clinical trials and at twice the placebo rate)

Nausea, vomiting, diarrhea, and aggression

Nausea, vomiting, dizziness, diarrhea, anorexia, weight loss of >7% while on therapy, and abdominal pain

Nausea, vomiting, diarrhea, and anorexia

Fatigue, swelling of extremities, dizziness, vomiting, anxiety, hallucinations, conjunctivitis, and sleep disturbances

Potential benefits

Some improvement or no decline in cognition (including memory, orientation, and language) and global functioning (performing daily activities such as bathing, dressing, and eating)

Stabilization or slower decline in cognition and global functioning

Time to noticeable effects

It may take up to 12 weeks for any of these drugs to begin working. The time it takes for patients to respond to any medication will vary from person to person, as will the type and length of response.